Paroxetine-d6 is intended for use as an internal standard for the quantification of paroxetine (Item No. 14998) by GC- or LC-MS. Paroxetine is a selective serotonin reuptake inhibitor (SSRI; Ki = 0.04 nM).1 It is selective for the serotonin transporter (SERT) over the dopamine and norepinephrine transporters (Kis = 400 and 90 nM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT2A, the histamine H1 receptor, α1– and α2-adrenergic receptors (α2-ARs), and muscarinic acetylcholine receptors (mAChRs; Kis = 21,168, 6,320, 13,746, 995, 3,915, and 42 nM, respectively).1,2 Paroxetine (5 mg/kg) decreases immobility time in the forced swim test in mice.3 Formulations containing paroxetine have been used in the treatment of depression, obsessive-compulsive disorder (OCD), panic disorder, social and generalized anxiety disorders, and post-traumatic stress disorder (PTSD).
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